refineR: Reference Interval Estimation using Real-World Data
Indirect method for the estimation of reference intervals (RIs) using Real-World Data ('RWD') and methods for comparing and verifying RIs. Estimates RIs by applying advanced statistical methods to routine diagnostic test measurements, which include both pathological and non-pathological samples, to model the distribution of non-pathological samples. This distribution is then used to derive reference intervals and support RI verification, i.e., deciding if a specific RI is suitable for the local population. The package also provides functions for printing and plotting algorithm results. See ?refineR for a detailed description of features. Version 1.0 of the algorithm is described in 'Ammer et al. (2021)' <doi:10.1038/s41598-021-95301-2>. Additional guidance is in 'Ammer et al. (2023)' <doi:10.1093/jalm/jfac101>. The verification method is described in 'Beck et al. (2025)' <doi:10.1515/cclm-2025-0728>.
| Version: | 2.0.0 |
| Depends: | R (≥ 3.2.0) |
| Imports: | stats, ash, future, future.apply, parallel, graphics, grDevices |
| Suggests: | knitr, rmarkdown |
| Published: | 2025-11-06 |
| DOI: | 10.32614/CRAN.package.refineR |
| Author: | Matthias Beck 
[aut, cre],
Tatjana Ammer
[aut],
Christopher M Rank [aut],
Andre Schuetzenmeister
[aut] |
| Maintainer: | Matthias Beck <matthias.beck.mb1 at roche.com> |
| License: | GPL (≥ 3) |
| NeedsCompilation: | no |
| Materials: | NEWS |
| CRAN checks: | refineR results |
Documentation:
Downloads:
| Package source: | refineR_2.0.0.tar.gz |
| Windows binaries: | r-devel: refineR_1.6.2.zip, r-release: refineR_1.6.2.zip, r-oldrel: refineR_1.6.2.zip |
| macOS binaries: | r-release (arm64): refineR_1.6.2.tgz, r-oldrel (arm64): refineR_1.6.2.tgz, r-release (x86_64): refineR_1.6.2.tgz, r-oldrel (x86_64): refineR_1.6.2.tgz |
| Old sources: | refineR archive |
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